capsid protein

By Targets:	Apoptosis (1) Bacterial (2) CDK (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Enterovirus (4) HBV (5) HIV (2) Reactive Oxygen Species (1)
By Research Areas:	Infection (12) Inflammation/Immunology (2) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148348

AB-836

HBV Infection

AB-836 is an orally active HBV capsid inhibitor. AB-836 inhibits viral replication by interacting with HBV core protein .

AB-836	HBV	Infection
AB-836 is an orally active HBV capsid inhibitor. AB-836 inhibits viral replication by interacting with HBV core protein .

HY-120072

PF-3450074 3 Publications Verification PF-74	HIV	Infection
PF-3450074 (PF-74) is a specifical inhibitor of *HIV-1 capsid* protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC₅₀**=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

HY-146011

HBV-IN-21	HBV DNA/RNA Synthesis	Infection
HBV-IN-21 (Compound II-8b) is an HBV DNA replication inhibitor with an IC₅₀ of 2.2 µM. HBV-IN-21 can interact HBV 4 capsid protein with good affinity (K_D = 60.0 μM) .

HY-142468

HIV-1 inhibitor-12	HIV	Infection
HIV-1 inhibitor-12 is potent HIV-1 inhibitor. HIV-1 inhibitor-12 inhibits HIV-1 capsid protein polymerization with an IC₅₀ of 9 nM (WO2021104413A1, compound 1-1a) .

HY-145850

EV-A71-IN-1	Enterovirus	Infection
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC₅₀ of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC₅₀>56.2 μM) .

HY-124364

RO6889678	HBV Cytochrome P450	Infection Metabolic Disease
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation .

HY-W012017

2-Hydroxytetradecanoic acid	Enterovirus	Infection
2-Hydroxytetradecanoic acid is a hydroxy fatty acid that inhibits cleavage between the enterovirus capsid proteins VP4 and VP2. 2-Hydroxytetradecanoic Acid has anti-virus activity .

HY-148768

AB-506	HBV	Inflammation/Immunology
AB-506 is an orally active inhibitor of HBV replication targeting the viral core protein. AB-506 can bind to HBV core protein, accelerate capsid assembly and inhibit HBV pgRNA encapsidation. AB-506 can be used in chronic hepatitis B (CHB) research .

HY-N2036

Mosloflavone	Enterovirus Bacterial	Infection
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-114314

BA-53038B	HBV	Infection
BA-53038B is a *HBV core protein* allosteric modulator (CpAM)*, binding to the HAP pocket and modulating HBV capsid* assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC₅₀ value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B .

HY-W019806

Lacto-N-fucopentaose I LNFP I	Endogenous Metabolite CDK Reactive Oxygen Species Apoptosis Enterovirus Bacterial	Infection Inflammation/Immunology
Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote CDK2 and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development .

Cat. No.	Product Name	Target	Research Area

HY-P0302

HEX3

Peptides Infection

HEX3 is a fragment of the adenoviral hexon. Hexon is the major capsid protein of adenovirion and is comprised of three identical polypeptide chains.

HEX3	Peptides	Infection
HEX3 is a fragment of the adenoviral hexon. Hexon is the major capsid protein of adenovirion and is comprised of three identical polypeptide chains.

HY-P0327

T7 Tag Peptide 1 Publications Verification	Peptides	Others
T7 Tag Peptide is a protein tag derived from the N-terminal 11 residues of the major T7 capsid protein, gp 10. T7 Tag Peptide can be used in different immunoassays as well as affinity purification .

HY-P0327A

T7 Tag Peptide TFA 1 Publications Verification	Peptides	Others
T7 Tag Peptide TFA is a protein tag derived from the N-terminal 11 residues of the major T7 capsid protein, gp 10. T7 Tag Peptide TFA can be used in different immunoassays as well as affinity purification .

Cat. No.	Product Name	Target	Research Area

HY-P99438

Anivovetmab KIND-030	Inhibitory Antibodies	Infection
Anivovetmab (KIND-030) is an anti-VP2 (parvovirus major capsid protein) monoclonal antibody (IgG2 type). Anivovetmab has the potential to study canine parvovirus infection.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0302

HEX3	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Others
HEX3 is a fragment of the adenoviral hexon. Hexon is the major capsid protein of adenovirion and is comprised of three identical polypeptide chains.

HY-N2036

Mosloflavone	Infection Flavonoids Monophenols Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Plants Disease Research Fields	Enterovirus Bacterial
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-W019806

Lacto-N-fucopentaose I LNFP I	Infection Structural Classification Natural Products Polysaccharides Classification of Application Fields Animals Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite CDK Reactive Oxygen Species Apoptosis Enterovirus Bacterial
Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote CDK2 and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development .

Species:	Virus (10)
Tag:	His (10) Myc (1)
Source:	Sf9 insect cells (3) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P73924

	p24 Protein, HIV-1 (AAB50258, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (AAB50258, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag. The total length of p24 Protein, HIV-1 (AAB50258, His) is 231 a.a., with molecular weight of ~27 kDa.

HY-P73925

	p24 Protein, HIV-1 (AAA44868, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (AAA44868, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag. The total length of p24 Protein, HIV-1 (AAA44868, His) is 231 a.a., with molecular weight of ~27 kDa.

HY-P73923

	p24 Protein, HIV-1 (AAB61122, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (AAB61122, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag. The total length of p24 Protein, HIV-1 (AAB61122, His) is 231 a.a., with molecular weight of ~27 kDa.

HY-P73922

	p24 Protein, HIV-1 (ACI05538, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (ACI05538, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag. The total length of p24 Protein, HIV-1 (ACI05538, His) is 231 a.a., with molecular weight of ~26.5 kDa.

HY-P73921

	p24 Protein, HIV-1 (BAH97658, His) CA; capsid protein; HIV1 Gag p24; Gag polyprotein; Pr55(Gag)	Virus	E. coli
	The capsid protein p24 forms the conical core of the genome RNA-nucleocapsid complex in the virion. Promote immune invasion by hiding the viral DNA detected by CGAS. The viral capsid protein p24 is considered to be another early virological biomarker of infection. p24 Protein, HIV-1 (BAH97658, His) is the recombinant Virus-derived p24 protein, expressed by E. coli , with C-His labeled tag. The total length of p24 Protein, HIV-1 (BAH97658, His) is 232 a.a., with molecular weight of ~27 kDa.

HY-P74622

	*Porcine circovirus 2 Capsid* protein (sf9, His)** capsid protein; Cap; ORF2	Virus	Sf9 insect cells
	The porcine circovirus 2 capsid protein autonomously constructs the icosahedral capsid of the viral particle, which is essential for initial attachment to host cell surface proteoglycans. Small size contributes to environmental stability and disinfectant resistance. Porcine circovirus 2 Capsid protein (sf9, His) is the recombinant Virus-derived Porcine circovirus 2 Capsid protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Porcine circovirus 2 Capsid protein (sf9, His) is 192 a.a., with molecular weight of ~23.8 kDa.

HY-P74354

	Capsid protein, Hepatitis B Virus (His) capsid protein; Core antigen; C protein; HBcAg	Virus	E. coli
	Capsid proteins play a key role in the assembly of icosahedral capsids, forming T=4 and T=3 particles. Transported along microtubules to the nucleus, its phosphorylation exposes a nuclear localization signal that promotes binding to nuclear pore complexes via α and β import. Capsid protein, Hepatitis B Virus (His) is the recombinant Virus-derived Capsid protein, expressed by E. coli , with C-His labeled tag. The total length of Capsid protein, Hepatitis B Virus (His) is 149 a.a., with molecular weight of ~17.67 kDa.

HY-P72302

	*Intermediate capsid* protein VP6, Rotavirus A (sf9, His, Myc)** Intermediate capsid protein VP6	Virus	Sf9 insect cells
	The intermediate capsid protein VP6 self-assembles into an icosahedral capsid with T=13 symmetry, forming the middle layer of the virus particle. It contains 230 VP6 trimers that protect dsRNA and prevent host cell antiviral responses. Intermediate capsid protein VP6, Rotavirus A (sf9, His, myc ) is the recombinant Virus-derived Intermediate capsid protein VP6, expressed by Sf9 insect cells , with N-His, C-Myc labeled tag. The total length of Intermediate capsid protein VP6, Rotavirus A (sf9, His, myc ) is 397 a.a., with molecular weight of ~48.8 kDa.

HY-P75291

Dengue virus Capsid Protein (His)

death-domain associated protein; Dengue virus DENV-2 (Strain New Guinea C) capsid protein / DENV-C protein
Virus E. coli

HY-P72307

	*Major capsid* protein VP1 Protein, Murine polyomavirus (Sf9, His)** Major structural protein VP1	Virus	Sf9 insect cells
	The major capsid protein, the VP1 protein, is a 40 nm diameter icosahedral capsid composed of 72 pentamers linked by disulfide bonds. During infection, VP1 participates in nucleosome rearrangement and encapsulates replicated genomic DNA. Major capsid protein VP1 Protein, Murine polyomavirus (Sf9, His) is the recombinant Virus-derived Major capsid protein VP1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Major capsid protein VP1 Protein, Murine polyomavirus (Sf9, His) is 372 a.a., with molecular weight of ~42.5 kDa.


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